STRESS MANAGEMENT

STRESS MANAGEMENT

Stress may be extremely common, but that doesn’t make it any less of a problem for those having to deal with it. Whether it’s particular moments that get you worked up or more of a chronic, underlying stress issue, many of the 6 million people who have tried CBD find that a regular dose of a high-quality product is all they need to not only cope in times of acute stress, but modulate their overall stress responses too. The same could be true for you – for a variety of reasons.

Due to CBD being a pleiotropic (something which affects various processes through multiple molecular pathways) there are all sorts of ways CBD interacts with the body which are currently at the forefront of theories as to how CBD oil can help modulate stress. As it stands, the endocannabinoid system (ECS) is starting to be considered as one of the most integral regulators of stress response.

Anandamide – the gate keeper of stress

Although a lot of people use CBD to tackle stress as and when it arises, most evidence suggests that the accumulation of cannabinoids in your body will be what really makes the biggest difference. Chronic stress is speculated as being one main contributors to an ‘endocannabinoid deficiency’, something which occurs when your own, internally produced cannabinoids anandamide and 2-AG have fallen into short supply. The result of this is a wholly unbalanced body, which can lead to issues such as fatigue, illness, skin conditions and, in a word, disease. On top of this, a lack of anandamide can equate to an excessive release of stress hormone cortisol, resulting in an easily triggered or constantly active fight or flight response – even at times when this reaction isn’t required or appropriate.

According to a 2016 Neuropsychopharmacology research paper titled ‘Neurobiological Interactions Between Stress and the Endocannabinoid System’, a decline in anandamide appears to activate the hypothalamic–pituitary–adrenal (HPA) axis – a process which ultimately results in increased levels of cortisol in the blood. In a balanced body, this is a vital part of survival instinct, but when your endocannabinoid levels are off kilter this can occur not only in times of acute stress, but at the drop of a hat. Long-term, this elevated stress can end up in any number of physical and mental ailments, including adrenal burnout, which then leads to a further demise of endocannabinoids. And round and round it goes.

When you take CBD, a range of things happen all at once. When it comes to stress, one of the most important actions is the inhibition of enzyme FAAH, which breaks down anandamide. As a result, higher levels of anandamide are allowed to flow freely around your body, making its way to the brain where it can influence the HPA axis – our central stress response system.

If CBD oil is taken on a regular basis, studies currently indicate that its accumulative nature means an overall higher levels of anandamide which can then block the unnecessary release of cortisol. A stress gate-keeper we could all do with.

CBD, Serotonin & Dopamine

When you do a little surface research into how CBD interacts with the body, you’re likely to read almost entirely about how it binds to the receptors in the endocannabinoid system. However, it’s really THC which appears to play the biggest role in ECS activation – CBD actually has a fairly low affinity for CB2 receptors, and indirectly activates them rather than directly activating them. In short, where THC fits into CB1 receptors like a lock and key, CBD sits imperfectly in CB2 receptors, blocking them rather than activating them. This, as above, is still a fascinating part of the process which seems to aid the flow of anandamide, but it’s not where CBD’s role ends.

Clinical studies now indicate that CBD does directly activate other receptors in the body, including serotonin receptors and dopamine receptors – both of which are key neurotransmitters in the brain linked to stress and depression. There’s still a lot of research that needs to be done into the potential this interaction holds, but there are high hopes for its positive impact of mood, pain and even addiction.

One recent test on rats showed that induced stress over the course of 24 days resulted in decreased serotonin activity. After seven days of treatment with CBD, these levels were completely normalised.

Although dopamine is mostly associated with the ‘reward response’ (getting a happy rush when you eat a new food, for example) there is now also evidence to suggest that chronic stress dampens dopamine production – something which can cause vulnerability to mental illness and addictive behaviour. The relationship between CBD, THC and dopamine is still largely unknown, but thus far data suggests that cannabinoids increase dopamine neural firing.

With all this in mind, it’s no surprise that plenty of CBD fans are sharing their anecdotal experiences of reduced stress after making the cannabis plant a part of their daily lives! We’d love to hear yours.

 

 

 

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677118/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316151/

https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/cortisol-serotonin-and-depression-all-stressed-out/766A58A46F537EA85FB5CB9AEDF33552

https://www.sciencedaily.com/releases/2016/09/160913134017.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405830/

 

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CBD DOSAGE

CBD DOSAGE

Whether you’ve just bought your very first CBD oil or you’ve been taking it for a while, figuring out the unique dosage that works best for you is something that many people struggle with. Understandably.

As with so much in this industry, lack of regulation and clinical trials means that there’s really no definitive answer on the maximum mg recommended per day, let alone what people should or shouldn’t be taking for the huge variety of reasons the world loves CBD.

However, that’s not to say there are no guidelines whatsoever – just not official ones. It’s estimated that over 6.9 million people in the UK alone are now taking CBD on a daily basis, so in lieu of hard and fast rules, we do have anecdotal evidence to suggest preferred doses.

But first things first – did you know that one bottle of 500mg CBD oil (or 250mg, or 1000mg or any amount) can differ considerably in the amount of CBD you get per drop? This comes down to one very simple thing that often gets overlooked – the ml contained within that bottle.

Seems obvious now you read it, right? But this tiny yet extremely significant point makes all the difference in many ways, for example:

  • The amount you take
  • The amount you’ll spend
  • The effects you’ll feel

It’s a pretty big deal.

How do you work out your dose?

The mg per dose and mg per day you choose to take is entirely personal preference and, because of that, it may take a bit of time and experimenting to learn what you like. The trick is to start low and build up gradually and, as a loose guideline, don’t take more than 200mg per day. Although studies performed on humans have used doses ranging from 20mg per day to 1500mg per day!

But before you do that, you need to work out how much CBD you’re getting per drop. Some CBD oil products will have this information on the packaging, but others won’t. If you need to figure it out yourself, just perform this easy sum:

Mg ÷ ml = CBD per 1ml dropper

You’ll then need to divide this amount by the number of drops in the 1ml dropper. This is usually 20, but (if it doesn’t state on the packaging) it’s best to contact the brand to find out.

Now you have the amount of CBD per drop, you can better control the tailoring process. It’s really vital information to have, as one 30ml bottle of 500mg will contain approx. 17mg per 1ml, whereas a 10ml bottle of 500mg will contain 50mg per 1ml dropper.

As CBD is officially a food supplement in the UK, not intended to treat or cure, we are unable to advise on doses for different uses. However, popular opinion among CBD fans is that higher doses are better for pain management and sleep, and lower doses tend to be preferred for stress, anxiety, energy and focus. But what you enjoy best will depend on a number of factors:

  • Your body weight
  • Your body chemistry
  • What you are using CBD for
  • Your CBD tolerance

It can be very helpful to clarify your CBD goals before starting out and to track your progress in a journal. It’s also worth noting that research suggests the total amount of CBD oil absorbed (when taken sublingually) is 5 x more effective when taking shortly after eating, as blood flow is increased to the mouth. And the longer you can hold it under your tongue, the better (ideally 1.5 minutes).

What about other CBD products?

Of course, CBD oil in a dropper bottle is not the only form CBD comes in. There are capsules, vapes, topicals, edibles, drinks, suppositories, sprays, patches and more! So, how do you work out your dosage with those?

CBD vapes, edibles, drinks and sprays are harder to tailor to an exact, individual dose than drops, however there are usually instructions on products like these, indicating the mg CBD you’re getting per puff/square of choc or sweet/drink/squirt. You’ll just have to familiarise yourself with these and be aware that they can differ from one brand to the next. As above, it’s generally best to start low and build up. Take a small first dose, wait an hour to see you feel and top up accordingly.

When it comes to capsules, the mg CBD per capsule will generally be much high than a drop of oil, but this doesn’t mean you’ll be getting that amount in your bloodstream, activating and binding to your endocannabinoid receptors. This is due to the bioavailability of CBD products (a subject we’ll cover in more depth in a future blog). Bioavailabilty of capsules and edibles in much lower than oils and vapes, as it will go through the digestion process and be metabolised by the liver before it gets to work.

With topicals, although what goes onto your skin will go in to some degree, the CBD will largely be utilised by local CB receptors on and in the layers on the skin. Some CBD topicals are designed for transdermal activity (muscle rubs, for example), but still very little CBD will enter your bloodstream – so have at it!

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CBD Extraction Methods

EXTRACTION METHODS

There are so many factors to take into account when shopping for high quality CBD – and these really are things that need to be adhered to, because it’s a serious matter. Anything you choose to put onto or into your body should always be selected with care, but when it comes to hemp it’s all the more important to find the purest option available.

There are a variety of extremely good reasons for this, including:

  1. The hemp/cannabis plant has the ability to suck up everything from the ground it’s planted in. All the nutrients and minerals in the earth, all the goodness from the plants around it, and all the toxic chemicals that might be used during the growing process. Because of this, industrial hemp crops are often grown to clean up contaminated land with the, now harmful, plant matter then being sold off for cheap CBD products. Even pesticide use is enough to render this amazing plant too poisonous for you to ideally want to mess with. So first and foremost, your CBD product must be organic.
  2. The extraction method used to obtain the cannabinoids, terpenes and flavonoids for CBD oil makes a huge difference to the end product. Largely because this is the point where it’s decided which molecules actually get through the procedure – and therefore, into the bottle. Not only this, but the extraction method used can again make the difference between a contaminated product and a clean one, which I’ll go into in more detail below.
  3. The mg amount of CBD printed on the label (and the other cannabinoids for that matter) is not always the truth. Spot testing across the UK in recent years has revealed a large number of CBD products on the market are not all they claim to be. You can read a bit more about this here. To avoid being conned, make sure your CBD products are always 3rd party lab-tested and have the results to prove it.

Let’s delve a little into extraction methods, how these differ and which is best. There are two main options most CBD brands will use:

C02 Extraction Method

The most expensive way and the best way. There is no other method which extracts all desirable parts of the plant in a completely clean manner, and leaves all the bits you don’t want behind. It’s safe, it’s chemical free, it’s eco friendly and it produces the best quality oil in the greatest yield.

There are three different ways of doing this – supercritical, mid-critical and subcritical. They all begin the same, using a specialist machine to compress Co2 gas into cold liquid form which can then be used like a solvent but without any toxic chemicals. From here, there are a few different ways to go for different effects.

Supercritical

Now this is pretty cool. A supercritical fluid is when that liquid mentioned above is put under high temperature and pressure until it reaches a point in density where liquid and gas phased do not exist. The makes for a gas which behaves like liquid.

When this supercritical fluid is passed through cannabis sativa flowers, it simply and efficiently pulls out trichomes (which contain the densest amount of cannabinoids, including CBD and THC) and terpenes. The liquid and matter is then separated and then the Co2 can be reused. This is a great method for pure extraction, but the harsh nature of it means some precious terpenes and cannabinoids are lost. It will also have to go through another process to remove larger molecules, like chlorophyll, which when left in CBD oil can make you feel a little sick.

Subcritical

Opposite to supercritical, subcritical uses low pressure and low temperature to remove the cannabinoids and terpenes. As a result, the process takes longer and is less efficient, but certain fragile terpenes and cannabinoids are saved by taking the extra time. Better still, large molecules such as the unwanted chlorophyll can’t make it through. This is the premium choice for full spectrum products.

 Mid Critical

There’s also the option of mid-critical which merges both supercritical and subcritical processes and meets somewhere in the middle.

Solvent Extraction

It’s quick, easy, flammable, potentially dangerous and damaging to delicate plant matter: solvent extraction is the preferred method for brands wanting to make money at your expense.

Using either ethanol, butane, propane, isopropyl, or alcohol, it’s possible to rapidly dissolve plant waxes and pull out some cannabinoids and terpenes. The larger molecules like chloropyhll also get through. The liquid is then put through an evaporation process to separate everything out, but solvent residue can be left on the matter which then makes its way into the final CBD products.

Overall, Co2 extraction is the only real option here. CBD products made this way may be a little more expensive, but it’s well, well worth it.

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HEMP SEED OIL VS CBD OIL

HEMP SEED OIL VS CBD OIL.

Did you know that a pretty shocking number of products boasting CBD on the label actually contains none of this wonderful cannabinoid at all? Or carries a dose so low that consumers will be getting practically nothing other than carrier oils in their system. Spot testing across the UK and US over the last couple of years has revealed this to be the case and, although some brands are simply fibbing about the cannabinoid content delivered by their oil or offering it in products that just don’t work, others are marketing themselves to look like a CBD product but if you check the ingredients list you’ll find hemp/cannabis sativa seed extract or oil listed.

For anyone new to CBD this can be incredibly misleading. Isn’t CBD derived from hemp? Well, yes – but the cannabinoid content all comes down to the part(s) of the plant used.

Hemp (also known as, and listed on ingredients labels as, cannabis sativa) is largely what’s used to extract CBD from for products sold in the UK as it tends to be high in CBD and low in THC. Marijuana is the name used for cannabis (the same plant) with higher levels of THC. However, cannabinoids – be that CBD, THC, CBG or any other of the approx. 120 cannabinoids found in the cannabis plant – are found in the greatest profusion in the flowers, while the stalk and leaves contain less and the seeds none at all.

Yep, you read that right – hemp seeds contain no CBD (or any other cannabinoid) whatsoever. So if you’ve been using a hemp seed oil product in the hope it will deliver the same plethora of benefits as CBD oil, you’re going to be disappointed.

However, that’s not the say hemp seed oil has nothing to offer. This part of the cannabis plant is remarkable in it’s own right and makes another fantastic dietary supplement and skincare base – just not one which will bind to or activate your endocannabinoid system.

Hemp Seed Oil 101

Hemp seed oil, as you’ve probably guessed, is extracted purely from the seeds of the cannabis sativa plant. Unlike the flowers used to extract cannabinoids, this can be from plants that are grown in the UK.

Although you won’t find any cannabinoids in your hemp seed oil, what you will find is a hefty dose of vitamins and minerals (vitamins E, B, B1, and B2 potassium, magnesium to name a few) as well as all 21 amino acids and a perfect balance of Omega 6 (Linoleic) to Omega 3 (alpha-Linolenic) which is not found in any other natural oil. These essential fatty acids are not produced by the human body, but are vital for keeping optimum health.

In skin care…
Endocannabinoid receptors can be found in almost every skin cell, so CBD skincare has a deeply impressive effect on skin health. Hemp seed oil offers a range of benefits too, just in a completely different way.

– Hemp seed oil is high in antioxidants, anti-inflammatory and exceptionally gentle, making it a great carrier oil for aging or spot-prone skin
– It’s also non-comedogenic, meaning it won’t clog your pores
– That perfect ratio of Omega 3 and 6, plus the full range of 21 amino acids makes hemp seed oil very moisturising. Gamma-linolenic acid (GLA), oleic acid and stearidonic acid are all used by a part of the cell membrane that is vital for cell function so applying this oil to troubled skin can help it to naturally re-balance.
– Hemp seed oil is densely nutritious – your skin will love you for all that vitamin E, carotene, phytosterols, phospholipids, sulfur, potassium, phosphorus, calcium, magnesium, iron and zinc.

As a sleep aid…
When you take a high quality CBD product, the cannabinoids will make their way to your CB1 and CB2 receptors to alter their function. These include ones known to affect pain, mood, body temperature and much more that can have an impact on your sleep. Hemp seed oil can also help you catch some seriously restorative zzzs’. There are a number of reasons for this:

– Both L-Tryptophan and vitamin B6 are found in hemp seeds and together, these create the precursor for melatonin – a hormone that regulates the sleep-wake cycle. By taking a spoonful of hemp seed oil every evening you will give your body the B6 it needs to trigger the conversion of tryptophan into serotonin, which your body can then convert into melatonin.
– If your body is low in fatty acids, you may have a melatonin deficiency. The unique combination of omega 3 and omega 6 found in hemp seed oil can quickly replenish your levels while also reducing stress and inflammation.
– 1-2 tablespoons of hemp seed oil (or 2-3 tbsp of hemp seeds) contains 39% of your magnesium RDA. Not only that, but it’s one of the most bioavailable sources of this mineral out there. Magnesium is involved in over 300 different enzyme reactions in the body’s cells, so if you’re running low you’re going to feel it. One of the most common symptoms of magnesium deficiency is insomnia, so topping up with hemp seed oil can be a quick fix for many people.

Of course this brief overview is only scratching the surface, but what we hope you can gather (and what we know to be true) is that cannabis sativa is the most amazing plant – from the seeds to the flowers.

Being clued up on the difference between CBD oil and hemp seed oil can help you make the buying choices best for your needs. But there’s no reason you should use both together, like in our hemp oil tincture! Just so long as you always buy from a trusted, organic source.

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THE HISTORY OF CBD

THE HISTORY OF CBD

Although the call for CBD across health, wellbeing, food and beauty industries has grown exponentially over recent years, its global use is actually nothing new – just something which has, thankfully, begun an intense revival. And as a result, the door has been swung open for burgeoning scientific study enabling us to finally learn more than ever before about the potential this incredible plant holds.

But despite the fact that research into cannabis sativa today (and the cannabinoids, terpenes and other components within) is still a very young science, there is evidence that this plant has been sowed by humans as an agricultural crop as far back as the end of the first ice age. Some of the earliest evidence of medicinal use dates back to 2700BC when emperor Shen Nung (historically dubbed ‘the Father of Chinese medicine’and ‘the divine farmer’for his introduction of agriculture to China and his investigations into a noted 365 herbs) readily prescribed marijuana tea for the treatment of gout, rheumatism, malaria, poor memory and more.

If we’ve known through practical use the benefits that the cannabis plant has to offer for so long, why is it that we’re only just seeing a resurgence of the widespread use of cannabis and cannabis derived CBD now?

The reason is simple: after thousands of years of encouraged cultivation and use (Henry VIII actually fined farmers is they didn’t grow hemp and by the early 18th century most physicians prescribed cannabis and included it in most medical formulations) both marijuana (cannabis indica) and hemp (cannabis sativa) were made completely illegal. This all started when around 5% of the US population had become, unwittingly, addicted to morphine – another ingredient commonly added to medications pre-19th century and one which, unsurprisingly, was extremely problematic. In an attempt to create some sort of boundaries for drug use, which until this point had been entirely free from restrictions, the Pure Food and Drug Act was put into place in 1906, creating the Food and Drug Administration (FDA). By 1914 drug use was defined as a crime for the first time, but even then, marijuana (the form of cannabis which contains psychoactive THC) was still legal for medicinal and industrial use, just now with ‘marijuana tax’ added. The UK followed suit, prohibiting the recreational use of marijuana in 1928.

By this point the medicinal waters were becoming a little muddied, so when President Richard Nixon waged his infamous ‘war on drugs’ in the 1960s as an alleged response to the rise in recreational drug use, lumping even THC free industrial hemp in with Heroin, cannabis was suddenly (officially) considered to have no medicinal use. Since then, theories have arisen to suggest there were sinister ulterior motives, such as an opportunity to criminalise ‘hippies’ and those of African American descent, as well as the chance to make a lot of money from re-introducing synthesised cannabis as a pharmaceutical drug at a later date. Again, the UK followed suit, listing cannabis and hemp as a Class B drug with the passage of the 1971 Misuse of Drugs Act.

So, what about CBD?

 As all of this caused an uproar in mainstream media, research into the cannabis plant was continuing quietly in the background.

In the early 1930s, British chemist Robert S. Cahn discovered the first partial structure of cannabinoid CBN which then went on to be fully identified in 1940. Just two years later American chemist, Roger Adams, successfully identified and isolated the CBD we know and love today. He also went on to discover the THC molecule. But still, understanding of how this plant produced the effects it was famous for remained a mystery, that is until Dr. Raphael Mechoulam unveiled the the first hint of the impact CBD has on the body, followed again by THC. Research continued through into the 1980s when Dr. Mechoulam conducted a breakthrough study into the application of CBD for epilepsy, where 8 subjects received a dose of 300mg CBD a day for four months. As a result, half the participants stopped having seizures altogether, while others experienced a dramatic decrease.

While evidence to suggest that the medicinal use of cannabinoids steadily grew, the reason for these effects remained a mystery until the early 90s, when further cannabinoids were discovered, along with the endocannabinoid system – a complex network of receptors within the human body (and many other species besides) which interacts with cannabinoids and is now considered to be one of the most important physiological systems for maintaining overall health.

Dr. Mechoulam wasn’t the only medical expert working away on uncovering the wonders of CBD – many other scientists were getting wise to its potential applications too. But due to the restrictions of use, performing studies was (and still is) tricky. But as more and more evidence supported the amazing attributes of this plant, a push for legalisation around the world bloomed. In 1996, California became the first state to legalise medical marijuana again. Over the years more US states followed. In the UK, cannabis containing THC remains illegal, but cannabis with little to no THC (or with THC removed) is allowed for the extraction and selling of CBD products and industrial hemp (for rope, clothes, hempcrete and more). In 2018 medical cannabis for exceptional cases was legalised under the radar in the UK and some cannabis derived medications, such as Sativex, are in circulation.

There’s still a stigma around cannabis use, but thanks to the lifting of restrictions in many areas of the world, a huge amount of research from over the past 30 years is now coming to light. What’s being found is astonishing and now, with billions of people discovering the wellbeing benefits of CBD, terpenes and over 100 other cannabinoids, we’re moving closer to an era where cannabis is celebrated for the wonder it truly is.

 

 

 

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WHAT IS THE ENDOCANNABINOID SYSTEM?

WHAT IS THE ENDOCANNABINOID SYSTEM? From glowing skin, free from long-standing troubles; deep, restorative sleep each and every night; a mind and body that is focused, calm and energised in a fast-paced era – the wellbeing world’s favourite supplement, CBD, has garnered the attention of millions of people all over the globe for what seems to be just about any issue. Those new to CBD and the other 120+ cannabinoids found within the cannabis sativa plant might well be wondering how one thing could possibly be so spectacular. How is it that this plant, which has been so controversial for so long, is being used with great success in such a huge variety of ways by an estimated (and ever-growing) 1.3M people in the UK alone, and around 42 million Americans?

 

It may all seem too good to be true. But in reality, there is very good reason why high quality hemp derived CBD products have the potential to deliver incredible and far reaching results. It all comes down to the endocannabinoid system that can be found inside each and every one of us.

 

What is the endocannabinoid system?

The endocannabinoid system (ECS) is, simply put, possibly the most important physiological system within the human body, along with other major networks including the immune system, nervous system and digestive system. This complex, cell-signalling network and its receptors spans every inch of us, within those other systems, in almost every skin cell throughout all of our bones, muscles, organs and more. It’s heavily indicated in many bodily processes including mood, sleep, appetite, fertility, memory, fine-tuning most of our physiological functions. Keeping this system working just as it should is vital in establishing and maintaining human health.

 

We produce our own version of the phytocannabinoids found in the hemp plant, called endocannabinoids. Most famously Anandamide, named after the Sanskrit word for ‘bliss’ thanks to it’s ability to reduce pain, inflammation and send feelings of euphoria among many other attributes. But the human body works in such a way that when Anandamide is released, an enzyme (FAAH) quickly gets to work breaking it down, limiting how far it can get and what it can do. Moreover, stress, lack of sleep, poor diet and many other things that impact our health on a daily basis can prevent us from producing enough of our endocannabinoids, potentially leading to a full body imbalance referred to as ‘endocannabinoid deficiency’. The result? Pretty much any health and wellbeing concern you can think of.

 

Despite being so crucial, the ECS was only discovered in 1992 when scientists delved into how psychoactive THC affects the human body. What they found was far beyond what anyone could have imagined – not only an extensive network, but a completely unique interaction between THC and this newly discovered system. As further studies followed, the role that CBD and all other cannabinoids play came to light, although as this is such a young science we’re still only at the cusp of discovering what our complete relationship with this plant is and the good it can do.

 

What we do know, is that THC mimics Anandamide without being broken down by fitting into our endocannabinoid receptors like a lock and key. This is partly responsible for the sensation of getting high when using THC laden marijuana. You won’t find any THC in our products, but what you will find is lots of CBD, which rather than slotting into those receptors, attaches itself neatly alongside it, altering the shape to stop Anandamide settling in which results in a free-flowing bliss molecule that we have naturally created. What’s more, CBD also inhibits the FAAH enzyme responsible for breaking Anandamide down, so it’s bliss inducing, healing effects can be felt further, stronger and longer.

 

When your body is out of balance and producing uncomfortable and unpleasant symptoms such as anxiety, insomnia, acne, hot flashes, aches and pains, one of the best things you can do to help yourself is to restore equilibrium. Using CBD on a regular basis has been shown to help your body do just this, nudging it gently to bring itself back to centre.

 

What are the endocannabinoid receptors?

There is still so much to discover about the ECS, but so far we are most familiar with two fundamental receptors: CB1 and CB2. These can be found throughout the body, in almost every skin cell, mast cells, in your brain, in your bones, in your gut, in your reproductive system…everywhere. And each receptor has an absolutely enormous impact on the way we feel, physically and mentally. The scientist Dr Ethan Russo responsible for the current endocannabinoid deficiency theory says: “If you don’t have enough endocannabinoids you have pain where there shouldn’t be pain. You would be sick, meaning nauseated. You would have a lowered seizure threshold. And just a whole litany of other problems.”

The CB1 receptors take care of appetite, mood, sleep, memory and perception (to name a few). CB2 receptors are most commonly found throughout the immune system and therefore largely control inflammation, pain and our immune response to pathogens. When you use a CBD product, you are giving your body a toolkit to alter these receptors and the impact that are having. Better still, as these receptors (and a many others besides) are so widespread, the effect is truly holistic, as CBD produces many different effects through a variety of molecular pathways and activates or binds to multiple receptors throughout the body. Essentially meaning it will go where it is needed and help your body do what needs to be done to restore homeostasis, which is why one person can have such a different CBD experience to the next.

 

As you can probably imagine, this overview is just scratching the surface of the complexities of the ECS. In future blogs, we’ll be looking at sister endocannabinoid 2-AG (which has been linked to our emotions, protection from seizure and cardiovascular health), ever-evolving ECS findings and further effects CBD and other cannabinoids have on your body. It’s an extremely exciting time in the world of CBD and we’re delighted to be able to share it with you!

 

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Third Party Testing

Hashtag Organics CBD is rigorously tested throughout the entire supply chain but that isnt enough to satisfy our quality standard. We also require a third-party, independent analysis to prove that out products contain what is listed on the label, are free of adulteration and meet the most stringent quality requirements.

Third Party Testing

Hashtag Organics CBD is rigorously tested throughout the entire supply chain but that isnt enough to satisfy our quality standard. We also require a third-party, independent analysis to prove that out products contain what is listed on the label, are free of adulteration and meet the most stringent quality requirements.

Our Promise

We strive to always offer accurate and objective information about CBD. We encourage the positive growth of the hemp industry while providing up-to-date information concering this plant. Our goal is to fight the spread of misinformation concerning CBD. We are committed to never exaggerating any scientific data on this subject, and we encourage others in the industry and online to follow our example.

Our Promise

We strive to always offer accurate and objective information about CBD. We encourage the positive growth of the hemp industry while providing up-to-date information concering this plant. Our goal is to fight the spread of misinformation concerning CBD. We are committed to never exaggerating any scientific data on this subject, and we encourage others in the industry and online to follow our example.

Hashtag Organics Ltd | Kyle House | Glasgow G22 7XS | Email: info@hashtagorganics.co.uk | Tel: 0141 255 1868

Hashtag Organics Ltd | Kyle House | Glasgow G22 7XS
Email: info@hashtagorganics.co.uk | Tel: 0141 255 1868

 

Klarna FAQ

 

Food and Drug Administration Disclosure. These statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease. Always check with your doctor or physician before starting a new dietary supplement programme. All Hashtag Organics products contain 0% THC.

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